Rupture of exomphalos and gastroschisis.

Novel exomphalos genetic mouse model: The importance of accurate phenotypic classification

BACKGROUND Rodent models of abdominal wall defects (AWD) may provide insight into the pathophysiology of these conditions including gut dysfunction in gastroschisis, or pulmonary hypoplasia in exomphalos. Previously, a Scribble mutant mouse model (circletail) was reported to exhibit gastroschisis. We further characterise this AWD in Scribble knockout mice. METHOD Homozygous Scrib knockout mic...

Exomphalos and Gastroschisis

Is the incidence of gastroschisis rising in South Africa in accordance with international trends? A retrospective analysis at Pretoria Academic and Kalafong Hospitals, 1981-2001.

OBJECTIVES Analysis of the incidence of gastroschisis compared with the incidence of exomphalos as a percentage of total paediatric surgical admissions. DESIGN Retrospective observational analysis using data from the ward admissions registers of the paediatric surgical wards of Pretoria Academic and Kalafong hospitals and from the weekly statistics sheets and audits thereof of the Paediatric ...

Exomphalos and Gastroschisis

Fetuses with exomphalos have an increased risk for chromosomal abnormalities. [7]Both exomphalos and gastroschisis have been linked to conditions affecting placental insufficiency, including maternal illness and infection, drug dependency and smoking. One study also found that ibuprofen during early pregnancy was a moderate risk factor for gastroschisis. Alcohol was a moderate risk factor for g...

Antenatal diagnosis of abdominal wall defects: a missed opportunity?

A review of six years' experience with antenatal diagnosis of abdominal wall defects by ultrasound showed its impact to be limited by poor detection rates. Twenty infants with exomphalos and 20 with gastroschisis were recorded but only 25 (63%) were diagnosed antenatally. The ultrasound false negative rate was higher for exomphalos (35%) than for gastroschisis (22%). No difference was detected ...